![]() For the methods recommended, the guidance addresses elements of their interpretation, their potential advantages and limitations and the evidence behind. Hence a comprehensive and efficient routine signal detection system will seek to integrate a number of different methods to prioritise the drug event combinations for further evaluation. This approach is based on the fact that, although disproportionality methods have demonstrated to detect many adverse reactions before other currently used methods of signal detection, this is not true for all types of adverse reactions. ![]() The proposed methods complement the classical disproportionality analysis with additional data summaries, based on both statistical and clinical considerations. The revised guidance on Screening for adverse reactions in EudraVigilance describes methods for screening adverse drug reactions used by the European Medicines Agency and national competent authorities. ENCePP Guide on Methodological Standards in Pharmacoepidemiologyġ1.3.
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